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Dosage and Administration
Tablets: 50 mg and 100 mg. Oral Solution: 50mg/5mL (10 mg/mL)
- Adult Patients: Initiate treatment in adults with 50 mg to 150 mg every 3 to 4 hours as needed for pain.
- Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
- Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse.
- Pediatric Patients: Initiate treatment with 1.1 mg/kg to 1.8 mg/kg orally, up to the adult dose, every 3 or 4 hours as needed for pain.
- Do not stop DEMEROL Tablets or Oral Solution abruptly in a physically dependent patient.
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- Significant respiratory depression.
- Acute or severe bronchial asthma in an unmonitored setting or in absence of resuscitative equipment.
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of having taken an MAOI.
- Known or suspected gastrointestinal obstruction, including paralytic ileus.
- Hypersensitivity to meperidine or to any other ingredients of the product.
Life-Threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients: Monitor closely, particularly during initiation and titration.
- Serotonin Syndrome: Potentially life-threatening condition could result from concomitant serotonergic drug administration. Discontinue DEMEROL Tablets or Oral Solution if serotonin syndrome is suspected.
- Adrenal Insufficiency: If diagnosed, treat with physiologic replacement of corticosteroids, and wean patient off of the opioid.
- Severe Hypotension: Monitor during dosage initiation and titration. Avoid use of DEMEROL Tablets or Oral Solution in patients with circulatory shock.
- Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors,
Head Injury or Impaired Consciousness: Monitor for sedation and respiratory depression. Avoid use of DEMEROL Tablets or Oral Solution in patients with impaired consciousness or coma. WIKI