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Dosage and Administration

The recommended initial dose is 5 mg for women and either 5 or 10 mg for men. In some patients, the higher morning blood levels following the use of the 10 mg dose increase the risk of next-day impairment of driving and other activities that require full alertness.

  • Use the lowest dose effective for the patient and must not exceed a total of 10 mg daily
  • Recommended initial dose is a single dose of 5 mg for women and a single dose of 5 or 10 mg for men, immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening
  • Geriatric patients and patients with mild to moderate hepatic impairment: the Recommended dose is 5 mg for men and women
  • Lower doses of CNS depressants may be necessary when taken concomitantly with AMBIEN
  • The effect of AMBIEN may be slowed if taken with or immediately after a meal


Side effects

Symptoms including insomnia, fatigue, lightheadedness, headaches, difficulty with coordination, stomach cramps, vomiting, sweating, and seizures.

  • “Sleep-driving” and other complex behaviors while not fully awake. Risk increases with dose and use with other CNS depressants and alcohol. Immediately evaluate any new onset behavioral changes
  • Depression: Worsening of depression or suicidal thinking may occur. Prescribe the least amount of tablets feasible to avoid intentional overdose.
  • Respiratory Depression: Consider this risk before prescribing in patients with compromised respiratory function
  • Hepatic Impairment: Avoid AMBIEN use in patients with severe hepatic impairment
  • Withdrawal effects: Symptoms may occur with rapid dose reduction or discontinuation
  • Severe Injuries: Drowsiness may lead to fall including severe injuries
  • With long-term use there is a risk of dependence. This is most likely to occur when the drug is taken for several weeks or at high doses.
  • People with a history of substance abuse are at a greater risk of developing dependence.


Observed reactions include anaphylaxis and angioedema Ambien is contraindicated in patients with known hypersensitivity to zolpidem tartrate or to any of the inactive ingredients in the formulation.


Keep AMBIEN in a safe place to prevent misuse and abuse. Depressant Effects and Next-Day Impairment AMBIEN, like other sedative-hypnotic drugs, has central nervous system depressant (CNS) effects. Co-administration with other central nervous system depressants (CNS) e.g. (antidepressants, opioids, tricyclic benzodiazepines, alcohol) increases the risk of central nervous system (CNS) depression. The use of AMBIEN with other sedative-hypnotics (including other zolpidem products) at bedtime or the middle of the night is not recommended.Dosage adjustments of AMBIEN and of other concomitant central nervous system (CNS) depressants may be necessary when AMBIEN is administered with such agents because of the potentially additive effects.


  • Do not take Ambien if you are allergic to anything in it.
  • Do not take Ambien if you are allergic to zolpidem or any other ingredients in Ambien
  • Do not take Ambien if you are allergic to zolpidem or any other ingredients in Ambien
  • Do not take Ambien if you have had an allergic reaction to drugs containing zolpidem,such as Ambien, Edluar, Zolpimist, or Intermezzo.
  • The risk of next-day psychomotor impairment, including impaired driving, is increased if

Ambien is taken with less than a full night of sleep remaining WIKI :

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